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Principal Investigator
Professor at the Faculty of Medicine and Health Sciences in University of Sherbrooke, Stephen Cunnane has a Ph. D. in physiology. Through his clinical research, he has worked for years to understand the link between nutrition, brain energy metabolism and cognitive functions during aging. Pr. Cunnane has published over 350 peer-reviewed research articles and 5 books. Pr. Cunnane was elected to the French National Academy of Medicine in 2009. In October 2017, he received the Chevreul Medal from the French Society for the Study of Lipids for his exceptional contributions in the field of omega fatty acid metabolism and the role of ketones in optimal brain function during aging.
Highlights:
- Fortier M, et al. (2021). A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT. Alzheimer and Dementia. 17(3): 543-552.
- Cunnane SC, et al. (2020). Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 19(9): 609-633.
- Roy, M, et al. (2021). A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment. Alzheimer's & Dementia. 7(1): e12217.
- Castellano, CA, et al. (2019). Links between metabolic and structural changes in the brain of cognitively normal older adults: a four year longitudinal follow-up. Frontiers in Aging Neuroscience. 11(15): 1-11.
- Fortier M, et al. (2019). A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimers Dement. 15(5): 625-634.
- Croteau É, et al. (2018). A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and Alzheimer's disease. Exp. Gerontology. 107(1): 18-26.
- Cunnane SC, et al.(2016). Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease. Front Mol Neurosci. 9: 53.
- Castellano CA, et al. (2015). Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimer's disease dementia. J. of Alz. Disease. 43(4): 1343-1353.
- Nugent S , et al. (2014). Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiology of Aging. 35(6): 1386-95.
- Cunnane S , et al. (2011). Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition. 27(1): 3-20.
Other publications : https://www.usherbrooke.ca/recherche/specialistes/details/stephen.cunnane/
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Medical Imaging Coordinator
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Research Centre on Aging
The Research Centre on Aging is well-known by its interdisciplinary research, ranging from biological studies, rehabilitation to the many social dimensions of aging. For over 30 years, the Centre has continued to improve targeting prevention as sphere of interest. Well-structured interventions can reduce the development of chronic disease and promote better aging. Achieving health in older people is the driving force behind the activities of the Research Centre on Aging.
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