Équipe de recherche sur le cerveau

Professeur Stephen Cunnane

Chercheur principal

Professeur titulaire à la Faculté de médecine et des sciences de la santé de l’Université de Sherbrooke, Stephen Cunnane possède un Ph. D. en physiologie. Par ses recherches cliniques, il travaille depuis des années à comprendre le lien entre la nutrition, le métabolisme énergétique cérébral et les fonctions cognitives au cours du vieillissement. Pr Cunnane a publié plus de 350 articles de recherche évalués par des paires et 5 livres. Le Pr Cunnane a été élu à l’Académie nationale de médecine française en 2009. En octobre 2017, il a reçu la médaille Chevreul de la Société française d’étude des lipides pour ses contributions exceptionnelles dans le domaine du métabolisme des acides gras oméga-3 et le rôle de cétones dans un fonctionnement cérébral optimal au cours du vieillissement.

Publications saillantes:

– Roy M, et al. (2022). A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment. Neurobiol Aging. 115, 77-87 [lire]
– Roy M, et al. (2021). A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment. Alzheimer’s Dement. 7(1): e12217. [lire]
– Myette-Côté É, et al. (2021). The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment. PLEFA. 169(June): 102236. [lire]
– Munawara U, et al. (2021). Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer’s disease. Immun Ageing. 18(1): 29. [lire]
– Fortier M, et al. (2021). A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT. Alzheimer Dement. 17(3): 543-552. [lire]
– Roy M, et al. (2020). Fascicle- and glucose- specific deterioration in white matter energy supply in Alzheimer’s disease. J Alzheimer’s Dis. 76(3): 863-881. [lire]
– Vandenberghe C, et al. (2020). Medium chain triglycerides modulate the ketogenic effect of a metabolic switch. Front Nutr. (7): 3. doi: 10.3389/fnut.2020.00003 [lire]
– Cunnane SC, et al. (2020). Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discovery. 19(9): 609-633. Impact factor 112; 17,000 accesses; 353 Citations; 172 Altmetric; top 2% of all papers published in 2020. [lire]
– Neth BJ, et al. (2020). Modified ketogenic diet is associated with improved cerebrosphinal fluid biomarker profike, cerebral perfusion, and cerebral ketone body uptake in older adults at-risk for Alzheimer’s disease: a pilot study. Neurobiol Aging. 86, 54-63. [lire]
– Cuenoud B, et al. (2020). Metabolism of exogenous D-beta-hydroxybutyrate, an energy substrate avidly consumed by the heart and kidney. Front Nutr. 7: 13. [lire]
– Castellano, CA, et al. (2019). Links between metabolic and structural changes in the brain of cognitively normal older adults: a four-year longitudinal follow-up. Front Aging Neurosci. 11(15): 1-11. [lire]
– St-Pierre V, et al. (2019). Plasma ketone and medium chain fatty acid response in humans consuming different medium chain triglycerides during a metabolic study day. Front Nutr. 6(46): 1-8. [lire]
– Fortier M, et al. (2019). A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment. Alzheimers Dement. 15(5): 625-634. [lire]
– Vandenberghe C, et al. (2019). A short-term intervention combining aerobic exercise with medium-chain triglyceride (MCT) is more ketogenic than either MCT or aerobic exercise alone: a comparison of normoglycemic and pre-diabetic older women. Appl Physiol Nutr Metab. 44(1): 66-73. [lire]
– Croteau E, et al. (2018). A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and Alzheimer’s disease. Exper Gerontol. 107(1): 18-26. [lire]
– Croteau E, et al. (2018). Ketogenic medium chain triglycerides increase brain energy metabolism in Alzheimer’s disease. J Alzheimer’s Dis. 64(2): 551-561. [lire]
– Castellano CA, et al. (2017). A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study. J Alzheimer Dis. 56(4): 1459-1468. [lire]
– Courchesne-Loyer A, et al. (2017). Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study. J Cereb Blood Flow Metab. 37(7): 2458-2493. [lire]
– St-Pierre V, et al. (2017). Butyrate is more ketogenic than leucine or octonoate-monoacylglycerol in healthy adult humans. J Funct Foods. 32(5): 170-175. [lire]
– Bernier M, et al. (2017). Spatial distribution of resting- state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging. NeuroImage. 4(15): 14-22. [lire]
– Courchesne-Loyer A, et al. (2017). Emulsification increases the acute ketogenic effect and bioavailability of mediumchain triglycerides in humans. Curr Dev Nutr. 7(1): 1-32. [lire]
– Vandenberghe C, et al. (2017). Caffeine intake increases plasma ketones: an acute metabolic study in humans. Can J Physiol Pharmacol. 95(4): 455-458. [lire]
– Vandenberghe C, et al. (2017). Tricaprylin alone increases plasma ketone response more than coconut oil or other medium chain triglycerides: an acute crossover study in healthy adults. Curr Dev Nutr. 1(4): e000257. [lire]